Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

Abstract Background Galectins are beta-galactose specific binding proteins. In human cancers, including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be overexpressed. In order to combat the dismal diagnosis and death rates of HCC, gene silencing and targeted inhibition of Gal...

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Main Authors: Zoe Leung, Frankie Chi Fat Ko, Sze Keong Tey, Ernest Man Lok Kwong, Xiaowen Mao, Bonnie Hei Man Liu, Angel Po Yee Ma, Yi Man Eva Fung, Chi-Ming Che, Danny Ka Ho Wong, Ching Lung Lai, Irene Oi-Lin Ng, Judy Wai Ping Yam
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-10-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Galectin-1
Hepatocellular carcinoma
miR-22
Therapeutics
OTX008
Acesso em linha:http://link.springer.com/article/10.1186/s13046-019-1402-x
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