TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties

Allogeneic mesenchymal stem cells (MSCs) are a promising cell therapy for treating numerous diseases, but major histocompatibility complex (MHC)-mismatched MSCs can be rejected by the recipient’s immune system. Pre-treating MSCs with transforming growth factor-β2 (TGF-β2) to downregulate surface exp...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Berglund, Alix K., Long, Julie M., Robertson, James B., Schnabel, Lauren V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889809/
https://ncbi.nlm.nih.gov/pubmed/33614658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.628382
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