Selective cysteines oxidation in soluble guanylyl cyclase catalytic domain is involved in NO activation

Nitric oxide (NO) binds to soluble guanylyl cyclase (GC1) and stimulates its catalytic activity to produce cGMP. Despite the key role of the NO-cGMP signaling in cardiovascular physiology, the mechanisms of GC1 activation remain ill-defined. It is believed that conserved cysteines (Cys) in GC1 modul...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Alapa, Maryam, Cui, Chuanlong, Shu, Ping, Li, Hong, Kholodovych, Vlad, Beuve, Annie
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889651/
https://ncbi.nlm.nih.gov/pubmed/33161042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.11.001
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