Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

Mechanical stimulation plays a crucial part in the development of intervertebral disc degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical microenvironment of the nucleus pulposus (NP) tissue, contributes to the pathogenesis of IDD. The mechanosensitive ion channel...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Wang, Bingjin, Ke, Wencan, Wang, Kun, Li, Gaocai, Ma, Liang, Lu, Saideng, Xiang, Qian, Liao, Zhiwei, Luo, Rongjin, Song, Yu, Hua, Wenbin, Wu, Xinghuo, Zhang, Yukun, Zeng, Xianlin, Yang, Cao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889339/
https://ncbi.nlm.nih.gov/pubmed/33628392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8884922
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