Paradoxical whole genome DNA methylation dynamics of 5’aza-deoxycytidine in chronic low-dose exposure in mice

Decitabine (5-aza-2ʹdeoxycytidine; DAC) is a DNA methyltransferase inhibitor used to hypomethylate the epigenome. Current dosing regimens of DAC for use in mice vary widely and their hypomethylating ability has not been robustly characterized, despite reliable results of hypomethylation of the epige...

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Библиографические подробности
Опубликовано в: :Epigenetics
Главные авторы: Colwell, Mathia, Wanner, Nicole M., Drown, Chelsea, Drown, Melissa, Dolinoy, Dana C., Faulk, Christopher
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889218/
https://ncbi.nlm.nih.gov/pubmed/32619143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1790951
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