Paradoxical whole genome DNA methylation dynamics of 5’aza-deoxycytidine in chronic low-dose exposure in mice

Decitabine (5-aza-2ʹdeoxycytidine; DAC) is a DNA methyltransferase inhibitor used to hypomethylate the epigenome. Current dosing regimens of DAC for use in mice vary widely and their hypomethylating ability has not been robustly characterized, despite reliable results of hypomethylation of the epige...

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Dettagli Bibliografici
Pubblicato in:Epigenetics
Autori principali: Colwell, Mathia, Wanner, Nicole M., Drown, Chelsea, Drown, Melissa, Dolinoy, Dana C., Faulk, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889218/
https://ncbi.nlm.nih.gov/pubmed/32619143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1790951
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