Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) encodes an enzyme that catalyzes de novo purine biosynthesis. Although PAICS has been implicated as a potential therapeutic target in several cancers, its clinical and prognostic significance...

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Udgivet i:PLoS One
Main Authors: Kobayashi, Yusuke, Kumamoto, Kensuke, Okayama, Hirokazu, Matsumoto, Takuro, Nakano, Hiroshi, Saito, Katsuharu, Matsumoto, Yoshiko, Endo, Eisei, Kanke, Yasuyuki, Watanabe, Yohei, Onozawa, Hisashi, Fujita, Shotaro, Sakamoto, Wataru, Saito, Motonobu, Momma, Tomoyuki, Takenoshita, Seiichi, Kono, Koji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888640/
https://ncbi.nlm.nih.gov/pubmed/33596246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247169
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