Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer

Colorectal cancer (CRC) cells often express Tn antigen, a tumor-associated truncated immature O-glycan (GalNAcα-O-Ser/Thr) that can promote tumor progression. Immunotherapies against Tn antigen have been developed and are being evaluated in clinical trials. Tn antigen can also be considered a novel...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Matsumoto, Takuro, Okayama, Hirokazu, Nakajima, Shotaro, Saito, Katsuharu, Nakano, Hiroshi, Endo, Eisei, Kase, Koji, Ito, Misato, Yamauchi, Naoto, Yamada, Leo, Kanke, Yasuyuki, Onozawa, Hisashi, Fujita, Shotaro, Sakamoto, Wataru, Saito, Motonobu, Saze, Zenichiro, Momma, Tomoyuki, Mimura, Kosaku, Kono, Koji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730766/
https://ncbi.nlm.nih.gov/pubmed/33260328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239081
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