Structure of human BCCIP and implications for binding and modification of partner proteins

BCCIP was isolated based on its interactions with tumor suppressors BRCA2 and p21. Knockdown or knockout of BCCIP causes embryonic lethality in mice. BCCIP deficient cells exhibit impaired cell proliferation and chromosome instability. BCCIP also plays a key role in biogenesis of ribosome 60S subuni...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Protein Sci
Prif Awduron: Choi, Woo Suk, Liu, Bochao, Shen, Zhiyuan, Yang, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Inc. 2021
Pynciau:
Protein Structure Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888581/
https://ncbi.nlm.nih.gov/pubmed/33452718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4026
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