Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study

[Image: see text] Cabotegravir (CAB) is an integrase strand-transfer inhibitor of HIV that has proven effective for HIV treatment and prevention in a long-acting injectable formulation, typically preceded by an oral formulation lead-in phase. Previous in vitro studies have demonstrated that CAB is p...

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Publicado en:ACS Pharmacol Transl Sci
Autores principales: Seneviratne, Herana Kamal, Hamlin, Allyson N., Li, Sue, Grinsztejn, Beatriz, Dawood, Halima, Liu, Albert Y., Kuo, Irene, Hosseinipour, Mina C., Panchia, Ravindre, Cottle, Leslie, Chau, Gordon, Adeyeye, Adeola, Rinehart, Alex R., McCauley, Marybeth, Eron, Joseph S., Cohen, Myron S., Landovitz, Raphael J., Hendrix, Craig W., Bumpus, Namandjé N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888308/
https://ncbi.nlm.nih.gov/pubmed/33615175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00181
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