Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

[Image: see text] Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of action against Mycobacterium tub...

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Publicado en:ACS Infect Dis
Autores principales: Oh, Sangmi, Libardo, M. Daben J., Azeeza, Shaik, Pauly, Gary T., Roma, Jose Santinni O., Sajid, Andaleeb, Tateishi, Yoshitaka, Duncombe, Caroline, Goodwin, Michael, Ioerger, Thomas R., Wyatt, Paul G., Ray, Peter C., Gray, David W., Boshoff, Helena I. M., Barry, Clifton E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887755/
https://ncbi.nlm.nih.gov/pubmed/33405882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00851
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