Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37

[Image: see text] The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic activity ranging from immunological to anti-neoplastic functions. However, its overexpression has been associated with harmful inflammatory responses and apoptosis. Thus, for the latter case...

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Vydáno v:ACS Pharmacol Transl Sci
Hlavní autoři: Quemé-Peña, Mayra, Ricci, Maria, Juhász, Tünde, Horváti, Kata, Bősze, Szilvia, Biri-Kovács, Beáta, Szeder, Bálint, Zsila, Ferenc, Beke-Somfai, Tamás
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887748/
https://ncbi.nlm.nih.gov/pubmed/33615169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00155
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