Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy

BACKGROUND: Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers to tumor immunity. However, we have previously shown that off-target delivery is a substantial problem during intratumoral injections; this can lead to diminished drug efficacy...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Muñoz, Nina M., Williams, Malea, Dixon, Katherine, Dupuis, Crystal, McWatters, Amanda, Avritscher, Rony, Manrique, Soraya Zorro, McHugh, Kevin, Murthy, Ravi, Tam, Alda, Naing, Aung, Patel, Sapna P., Leach, David, Hartgerink, Jeffrey D., Young, Simon, Prakash, Punit, Hwu, Patrick, Sheth, Rahul A.
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Oncolytic and Local Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887346/
https://ncbi.nlm.nih.gov/pubmed/33589526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001800
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