Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy

BACKGROUND: Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers to tumor immunity. However, we have previously shown that off-target delivery is a substantial problem during intratumoral injections; this can lead to diminished drug efficacy...

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Dades bibliogràfiques
Publicat a:J Immunother Cancer
Autors principals: Muñoz, Nina M., Williams, Malea, Dixon, Katherine, Dupuis, Crystal, McWatters, Amanda, Avritscher, Rony, Manrique, Soraya Zorro, McHugh, Kevin, Murthy, Ravi, Tam, Alda, Naing, Aung, Patel, Sapna P., Leach, David, Hartgerink, Jeffrey D., Young, Simon, Prakash, Punit, Hwu, Patrick, Sheth, Rahul A.
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2021
Matèries:
Oncolytic and Local Immunotherapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887346/
https://ncbi.nlm.nih.gov/pubmed/33589526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001800
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