Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer’s disease (AD). Due to the many limitations to study microglia in situ or isolated for large scale drug discovery applications, there is a high...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Reich, Marvin, Paris, Iñaki, Ebeling, Martin, Dahm, Nadine, Schweitzer, Christophe, Reinhardt, Dieter, Schmucki, Roland, Prasad, Megana, Köchl, Fabian, Leist, Marcel, Cowley, Sally A., Zhang, Jitao David, Patsch, Christoph, Gutbier, Simon, Britschgi, Markus
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887311/
https://ncbi.nlm.nih.gov/pubmed/33613545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.617860
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