Rare deleterious germline variants and risk of lung cancer

Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC). Whole exome plus targeted sequencing of germline DNA was performed on 1045 LC cases and 885 controls in the discovery set. To unveil the inherited causal varian...

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發表在:NPJ Precis Oncol
Main Authors: Liu, Yanhong, Xia, Jun, McKay, James, Tsavachidis, Spiridon, Xiao, Xiangjun, Spitz, Margaret R., Cheng, Chao, Byun, Jinyoung, Hong, Wei, Li, Yafang, Zhu, Dakai, Song, Zhuoyi, Rosenberg, Susan M., Scheurer, Michael E., Kheradmand, Farrah, Pikielny, Claudio W., Lusk, Christine M., Schwartz, Ann G., Wistuba, Ignacio I., Cho, Michael H., Silverman, Edwin K., Bailey-Wilson, Joan, Pinney, Susan M., Anderson, Marshall, Kupert, Elena, Gaba, Colette, Mandal, Diptasri, You, Ming, de Andrade, Mariza, Yang, Ping, Liloglou, Triantafillos, Davies, Michael P. A., Lissowska, Jolanta, Swiatkowska, Beata, Zaridze, David, Mukeria, Anush, Janout, Vladimir, Holcatova, Ivana, Mates, Dana, Stojsic, Jelena, Scelo, Ghislaine, Brennan, Paul, Liu, Geoffrey, Field, John K., Hung, Rayjean J., Christiani, David C., Amos, Christopher I.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887261/
https://ncbi.nlm.nih.gov/pubmed/33594163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00146-7
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