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G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide

Poly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they are important therapeutic targets for cancer treatment. Recent studies have revealed a close interplay between PARP1 recruitment and G-quadrupl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Dallavalle, Sabrina, Musso, Loana, Artali, Roberto, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Gargallo, Raimundo, Mazzini, Stefania
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887208/
https://ncbi.nlm.nih.gov/pubmed/33594142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83474-9
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