G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide

Poly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they are important therapeutic targets for cancer treatment. Recent studies have revealed a close interplay between PARP1 recruitment and G-quadrupl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Dallavalle, Sabrina, Musso, Loana, Artali, Roberto, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Gargallo, Raimundo, Mazzini, Stefania
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887208/
https://ncbi.nlm.nih.gov/pubmed/33594142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83474-9
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