HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall balance of this post-translational modification. HDAC inhibitors (HDACi) are potent agents that disrupt this balance and are used clinically to tre...

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Publicado no:Cell Rep
Main Authors: Slaughter, Mariesa J., Shanle, Erin K., Khan, Abid, Chua, Katrin F., Hong, Tao, Boxer, Lisa D., Allis, C. David, Josefowicz, Steven Z., Garcia, Benjamin A., Rothbart, Scott B., Strahl, Brian D., Davis, Ian J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886050/
https://ncbi.nlm.nih.gov/pubmed/33472068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108638
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