The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells

Hematopoietic and nervous systems are linked via innervation of bone marrow (BM) niche cells. Hematopoietic stem/progenitor cells (HSPCs) express neurotransmitter receptors, such as the γ-aminobutyric acid (GABA) type B receptor subunit 1 (GABBR1), suggesting that HSPCs could be directly regulated b...

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Vydáno v:Blood
Hlavní autoři: Shao, Lijian, Elujoba-Bridenstine, Adedamola, Zink, Katherine E., Sanchez, Laura M., Cox, Brian J., Pollok, Karen E., Sinn, Anthony L., Bailey, Barbara J., Sims, Emily C., Cooper, Scott H., Broxmeyer, Hal E., Pajcini, Kostandin V., Tamplin, Owen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885825/
https://ncbi.nlm.nih.gov/pubmed/32881992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004415
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