Genetic and environmental determinants of O(6)-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

BACKGROUND: Epigenetic inactivation of O(6)-methylguanine DNA-methyltransferase (MGMT) is associated with increased sensitivity to alkylating chemotherapeutic agents in glioblastoma patients. The genetic background underlying MGMT gene methylation may explain individual differences in treatment resp...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Wang, Lijie, Mohammadnejad, Afsaneh, Li, Weilong, Lund, Jesper, Li, Shuxia, Clemmensen, Signe, Timofeeva, Maria, Soerensen, Mette, Mengel-From, Jonas, Christensen, Kaare, Hjelmborg, Jacob, Tan, Qihua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885436/
https://ncbi.nlm.nih.gov/pubmed/33588926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-021-01009-5
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