Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition

BACKGROUND: Cyclooxygenase 2 (COX-2) promotes stemness in triple negative breast cancer (TNBC), highlighting COX-2 as a promising therapeutic target in these tumors. However, to date, clinical trials using COX-2 inhibitors in breast cancer only showed variable patient responses with no clear signifi...

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Bibliografiske detaljer
Udgivet i:Breast Cancer Res
Main Authors: Tian, Jun, Wang, Vivian, Wang, Ni, Khadang, Baharak, Boudreault, Julien, Bakdounes, Khldoun, Ali, Suhad, Lebrun, Jean-Jacques
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885389/
https://ncbi.nlm.nih.gov/pubmed/33588911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-021-01401-2
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