Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Nucleolar stress has been implicated in the pathology and disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) from repeat expansions of GGGGCC in C9orf72 (C9-ALS/FTLD) but not in sporadic ALS (SALS). Previously we reported that antisense RNA trans...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Aladesuyi Arogundade, Olubankole, Nguyen, Sandra, Leung, Ringo, Wainio, Danielle, Rodriguez, Maria, Ravits, John
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885352/
https://ncbi.nlm.nih.gov/pubmed/33588953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01125-6
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