Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions

Nrf2 is a redox-sensitive transcription factor that is thought to be important in protection against intracellular pathogens. To determine the protective role of Nrf2 in the host defense against Mycobacterium avium complex (MAC), both wild-type and Nrf2-deficient mice were intranasally infected with...

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Veröffentlicht in:mBio
Hauptverfasser: Nakajima, Masayuki, Matsuyama, Masashi, Kawaguchi, Mio, Kiwamoto, Takumi, Matsuno, Yosuke, Morishima, Yuko, Yoshida, Kazufumi, Sherpa, Mingma, Yazaki, Kai, Osawa, Hajime, Muratani, Masafumi, Ishii, Yukio, Hizawa, Nobuyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885113/
https://ncbi.nlm.nih.gov/pubmed/33563837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01947-20
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