Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely, the endogenous regulation of GDF15 and its physiol...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Klein, Anders B., Nicolaisen, Trine S., Ørtenblad, Niels, Gejl, Kasper D., Jensen, Rasmus, Fritzen, Andreas M., Larsen, Emil L., Karstoft, Kristian, Poulsen, Henrik E., Morville, Thomas, Sahl, Ronni E., Helge, Jørn W., Lund, Jens, Falk, Sarah, Lyngbæk, Mark, Ellingsgaard, Helga, Pedersen, Bente K., Lu, Wei, Finan, Brian, Jørgensen, Sebastian B., Seeley, Randy J., Kleinert, Maximilian, Kiens, Bente, Richter, Erik A., Clemmensen, Christoffer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884842/
https://ncbi.nlm.nih.gov/pubmed/33589633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21309-x
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