Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

AIMS/HYPOTHESIS: Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms are unknown. METHODS: DMPP (10 mg/kg body weight, s....

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Publicado no:Diabetologia
Main Authors: Jall, Sigrid, De Angelis, Meri, Lundsgaard, Anne-Marie, Fritzen, Andreas M., Nicolaisen, Trine S., Klein, Anders B., Novikoff, Aaron, Sachs, Stephan, Richter, Erik A., Kiens, Bente, Schramm, Karl-Werner, Tschöp, Matthias H., Stemmer, Kerstin, Clemmensen, Christoffer, Müller, Timo D., Kleinert, Maximilian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228898/
https://ncbi.nlm.nih.gov/pubmed/32140744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05117-4
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