Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation

Patients with a deficiency in very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that is involved in the mitochondrial beta-oxidation of long-chain fatty acids, are at risk for developing cardiac arrhythmias. In human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), VLCAD def...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Pharmacol
Päätekijät: Verkerk, Arie O., Knottnerus, Suzan J. G., Portero, Vincent, Bleeker, Jeannette C., Ferdinandusse, Sacha, Guan, Kaomei, IJlst, Lodewijk, Visser, Gepke, Wanders, Ronald J. A., Wijburg, Frits A., Bezzina, Connie R., Mengarelli, Isabella, Houtkooper, Riekelt H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883678/
https://ncbi.nlm.nih.gov/pubmed/33597881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.616834
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