Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

BACKGROUND: Cyclosporine A (CsA) is routinely used to treat patients with steroid‐refractory acute severe ulcerative colitis (ASUC). Here, we studied the underlying mechanisms of CsA‐mediated alleviation in ASUC patients. METHODS: Neutrophil functions including expression of cytokines, apoptosis, an...

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Pubblicato in:Clin Transl Med
Autori principali: Lu, Huiying, Lin, Jian, Xu, Chunjin, Sun, Mingming, Zuo, Keqiang, Zhang, Xiaoping, Li, Mingsong, Huang, Hailiang, Li, Zhong, Wu, Wei, Feng, Baisui, Liu, Zhanju
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7882115/
https://ncbi.nlm.nih.gov/pubmed/33634990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.334
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