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Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance

With the development of insulin resistance (IR), there is a compensatory increase in the plasma insulin response to offset the defect in insulin action to maintain normal glucose tolerance. The insulin response is the result of two factors: insulin secretion and metabolic clearance rate of insulin (...

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Bibliographic Details
Published in:Diabetes
Main Authors: Gastaldelli, Amalia, Abdul Ghani, Muhammad, DeFronzo, Ralph A.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881859/
https://ncbi.nlm.nih.gov/pubmed/33077684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1152
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