JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation

BACKGROUND: Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed that ASCs from DOP mice (DOP-ASCs) have a lower osteogenesis potential compared w...

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Udgivet i:Stem Cell Res Ther
Main Authors: Peng, Shuanglin, Shi, Sirong, Tao, Gang, Li, Yanjing, Xiao, Dexuan, Wang, Lang, He, Qing, Cai, Xiaoxiao, Xiao, Jingang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881648/
https://ncbi.nlm.nih.gov/pubmed/33579371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02163-6
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