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Metabolic-targeted Combination Therapy With Dichloroacetate and Metformin Suppresses Glioblastoma Cell Line Growth In Vitro and In Vivo
Background/Aim: We investigated the hypothesis that dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, and metformin (MET), an antidiabetic agent and complex I inhibitor, have synergistic cytotoxic effects in glioblastoma cells in vitro and in vivo. Materials and Methods: We performed...
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| Published in: | In Vivo |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
International Institute of Anticancer Research
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7880769/ https://ncbi.nlm.nih.gov/pubmed/33402483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/invivo.12265 |
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