Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response. What remains unclear is the mechanism by which PARP-7 regulates this process,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Rodriguez, Kelsie M, Buch-Larsen, Sara C, Kirby, Ilsa T, Siordia, Ivan Rodriguez, Hutin, David, Rasmussen, Marit, Grant, Denis M, David, Larry L, Matthews, Jason, Nielsen, Michael L, Cohen, Michael S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880690/
https://ncbi.nlm.nih.gov/pubmed/33475084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60480
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