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Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

Circadian rhythms are an integral part of physiology, underscoring their relevance for the treatment of disease. We conducted cell-based high-throughput screening to investigate time-of-day influences on the activity of known antitumor agents and found that many compounds exhibit daily rhythms of cy...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Lee, Yool, Fong, Shi Yi, Shon, Joy, Zhang, Shirley L., Brooks, Rebekah, Lahens, Nicholas F., Chen, Dechun, Dang, Chi Van, Field, Jeffrey M., Sehgal, Amita
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880601/
https://ncbi.nlm.nih.gov/pubmed/33579708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd2645
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