A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

The blood-brain barrier (BBB) is critical for neural function. We report here circadian regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with highest levels during the active phase and lowest during the resting phase. This oscillation is abrogated in circadian c...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Zhang, Shirley L., Lahens, Nicholas F., Yue, Zhifeng, Arnold, Denice M., Pakstis, Peter P., Schwarz, Jessica E., Sehgal, Amita
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841146/
https://ncbi.nlm.nih.gov/pubmed/33504784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20795-9
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