Prostaglandin E(2) promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T(regs)), yet how the microbiota-T(reg) cross-talk is physiologically controlled is incompletely defined. Here, we report that prostaglandin E(2)...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Crittenden, Siobhan, Goepp, Marie, Pollock, Jolinda, Robb, Calum T., Smyth, Danielle J., Zhou, You, Andrews, Robert, Tyrrell, Victoria, Gkikas, Konstantinos, Adima, Alexander, O’Connor, Richard A., Davies, Luke, Li, Xue-Feng, Yao, Hatti X., Ho, Gwo-Tzer, Zheng, Xiaozhong, Mair, Amil, Vermeren, Sonja, Qian, Bin-Zhi, Mole, Damian J., Gerasimidis, Konstantinos, Schwarze, Jürgen K. J., Breyer, Richard M., Arends, Mark J., O’Donnell, Valerie B., Iredale, John P., Anderton, Stephen M., Narumiya, Shuh, Maizels, Rick M., Rossi, Adriano G., Howie, Sarah E., Yao, Chengcan
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880593/
https://ncbi.nlm.nih.gov/pubmed/33579710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd7954
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