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Synthesis of 1,2-Dihydroquinolines via Hydrazine-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis.

The synthesis of 1,2-dihydroquinolines by the hydrazine-catalyzed ring-closing carbonyl-olefin metathesis (RCCOM) of N-prenylated 2-aminobenzaldehydes is reported. Substrates with a variety of substitution patterns are shown. With an acid-labile protecting group on the nitrogen atom, in situ deprote...

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Pubblicato in:Org Lett
Autori principali: Zhang, Yunfei, Sim, Jae Hun, MacMillan, Samantha N., Lambert, Tristan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880559/
https://ncbi.nlm.nih.gov/pubmed/32667809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02116
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