PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury

Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer. We therefore examined the role of the programmed...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Triantafyllou, Evangelos, Gudd, Cathrin L.C., Mawhin, Marie-Anne, Husbyn, Hannah C., Trovato, Francesca M., Siggins, Matthew K., O’Connor, Thomas, Kudo, Hiromi, Mukherjee, Sujit K., Wendon, Julia A., Bernsmeier, Christine, Goldin, Robert D., Botto, Marina, Khamri, Wafa, McPhail, Mark J.W., Possamai, Lucia A., Woollard, Kevin J., Antoniades, Charalambos G., Thursz, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880414/
https://ncbi.nlm.nih.gov/pubmed/33320839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140196
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