PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury

Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer. We therefore examined the role of the programmed...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Triantafyllou, Evangelos, Gudd, Cathrin L.C., Mawhin, Marie-Anne, Husbyn, Hannah C., Trovato, Francesca M., Siggins, Matthew K., O’Connor, Thomas, Kudo, Hiromi, Mukherjee, Sujit K., Wendon, Julia A., Bernsmeier, Christine, Goldin, Robert D., Botto, Marina, Khamri, Wafa, McPhail, Mark J.W., Possamai, Lucia A., Woollard, Kevin J., Antoniades, Charalambos G., Thursz, Mark R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880414/
https://ncbi.nlm.nih.gov/pubmed/33320839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140196
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