CD14(+) CD15(−) HLA-DR(−) myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure

OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14(+)HLA-DR(−) myeloid-derived suppressor cells (M-MDSCs) have recently been identified to quell antimicrobial responses in...

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Udgivet i:Gut
Main Authors: Bernsmeier, Christine, Triantafyllou, Evangelos, Brenig, Robert, Lebosse, Fanny J, Singanayagam, Arjuna, Patel, Vishal C, Pop, Oltin T, Khamri, Wafa, Nathwani, Rooshi, Tidswell, Robert, Weston, Christopher J, Adams, David H, Thursz, Mark R, Wendon, Julia A, Antoniades, Charalambos Gustav
Format: Artigo
Sprog:Inglês
Udgivet: Gut 2018
Fag:
Hepatology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969362/
https://ncbi.nlm.nih.gov/pubmed/28592438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-314184
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