Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV(+)) interneurons. PNNs restrict cortical network plasticity but the molecular mechanisms involved are unclear. We found that reacti...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Lesnikova, Angelina, Casarotto, Plinio Cabrera, Fred, Senem Merve, Voipio, Mikko, Winkel, Frederike, Steinzeig, Anna, Antila, Hanna, Umemori, Juzoh, Biojone, Caroline, Castrén, Eero
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880295/
https://ncbi.nlm.nih.gov/pubmed/33293360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2228-20.2020
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