The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction of cryptic transcripts associated with SF3B1 mutatio...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Leeksma, Alexander C., Derks, Ingrid A. M., Kasem, M. Haidar, Kilic, Emine, de Klein, Annelies, Jager, Martine J., van de Loosdrecht, Arjan A., Jansen, Joop H., Navrkalova, Veronika, Faber, Laura M., Zaborsky, Nadja, Egle, Alexander, Zenz, Thorsten, Pospisilova, Sarka, Abdel-Wahab, Omar, Kater, Arnon P., Eldering, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880055/
https://ncbi.nlm.nih.gov/pubmed/33585229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.609409
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares