The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction of cryptic transcripts associated with SF3B1 mutatio...

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Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Leeksma, Alexander C., Derks, Ingrid A. M., Kasem, M. Haidar, Kilic, Emine, de Klein, Annelies, Jager, Martine J., van de Loosdrecht, Arjan A., Jansen, Joop H., Navrkalova, Veronika, Faber, Laura M., Zaborsky, Nadja, Egle, Alexander, Zenz, Thorsten, Pospisilova, Sarka, Abdel-Wahab, Omar, Kater, Arnon P., Eldering, Eric
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880055/
https://ncbi.nlm.nih.gov/pubmed/33585229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.609409
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