The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction of cryptic transcripts associated with SF3B1 mutatio...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Leeksma, Alexander C., Derks, Ingrid A. M., Kasem, M. Haidar, Kilic, Emine, de Klein, Annelies, Jager, Martine J., van de Loosdrecht, Arjan A., Jansen, Joop H., Navrkalova, Veronika, Faber, Laura M., Zaborsky, Nadja, Egle, Alexander, Zenz, Thorsten, Pospisilova, Sarka, Abdel-Wahab, Omar, Kater, Arnon P., Eldering, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880055/
https://ncbi.nlm.nih.gov/pubmed/33585229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.609409
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi