Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense(®) Entry assay

BACKGROUND: Fostemsavir is a prodrug of a first-in-class HIV-1 attachment inhibitor, temsavir, that binds to gp120 and blocks attachment to the host-cell CD4 receptor, preventing entry and infection of the target cell. Previous studies using a limited number of clinical isolates showed that there wa...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Gartland, Margaret, Zhou, Nannan, Stewart, Eugene, Pierce, Amy, Clark, Andrew, Ackerman, Peter, Llamoso, Cyril, Lataillade, Max, Krystal, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879148/
https://ncbi.nlm.nih.gov/pubmed/33241285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa474
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