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Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation
Bmp plays an important role in cardiomyocyte differentiation, but the function of Smad4 in Bmp signaling remains elusive. Here, we show that disruption of the Smad4 gene in cardiac progenitors expressing Sfrp5 led to embryonic lethality with hypoplastic heart formation. Although the expression of Nk...
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| Gepubliceerd in: | Sci Rep |
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| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7878807/ https://ncbi.nlm.nih.gov/pubmed/33574455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82954-2 |
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