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A Lowly Populated, Transient β-sheet Structure in Monomeric Aβ(1–42) Identified by Multinuclear NMR of Chemical Denaturation

Chemical denaturation is a well-established approach for probing the equilibrium between folded and unfolded states of proteins. We demonstrate applicability of this method to the detection of a small population of a transiently folded structural element in a system that is often considered to be in...

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Detalhes bibliográficos
Publicado no:Biophys Chem
Main Authors: Kakeshpour, Tayeb, Ramanujam, Venkat, Barnes, C. Ashley, Shen, Yang, Ying, Jinfa, Bax, Ad
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878406/
https://ncbi.nlm.nih.gov/pubmed/33453683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2020.106531
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