High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

BACKGROUND & AIMS: Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, w...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Shinozawa, Tadahiro, Kimura, Masaki, Cai, Yuqi, Saiki, Norikazu, Yoneyama, Yosuke, Ouchi, Rie, Koike, Hiroyuki, Maezawa, Mari, Zhang, Ran-Ran, Dunn, Andrew, Ferguson, Autumn, Togo, Shodai, Lewis, Kyle, Thompson, Wendy, Asai, Akihiro, Takebe, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878295/
https://ncbi.nlm.nih.gov/pubmed/33039464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.10.002
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