Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase‐1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glycan optimization, and a novel biomanufacturing platform to enha...

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Enregistré dans:
Détails bibliographiques
Publié dans:Clin Transl Sci
Auteurs principaux: Stabach, Paul R., Zimmerman, Kristin, Adame, Aaron, Kavanagh, Dillon, Saeui, Christopher T., Agatemor, Christian, Gray, Shawn, Cao, Wenxiang, De La Cruz, Enrique M., Yarema, Kevin J., Braddock, Demetrios T.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877847/
https://ncbi.nlm.nih.gov/pubmed/33064927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12887
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