Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, sali...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Huijink, Tobias M., Venema, Leonie H., Posma, Rene A., de Vries, Nynke J., Westerkamp, Andrie C., Ottens, Petra J., Touw, Daan J., Nijsten, Maarten W., Leuvenink, Henri G.D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877823/
https://ncbi.nlm.nih.gov/pubmed/32702185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12846
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