Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, sali...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Huijink, Tobias M., Venema, Leonie H., Posma, Rene A., de Vries, Nynke J., Westerkamp, Andrie C., Ottens, Petra J., Touw, Daan J., Nijsten, Maarten W., Leuvenink, Henri G.D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877823/
https://ncbi.nlm.nih.gov/pubmed/32702185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12846
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