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A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity
The microtubule-associated protein Tau is strongly implicated in Alzheimer’s disease (AD) and aggregates into neurofibrillary tangles in AD. Genetic reduction of Tau is protective in several animal models of AD and cell culture models of amyloid-β (Aβ) toxicity, making it an exciting therapeutic tar...
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| Publicado en: | Neurobiol Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7877553/ https://ncbi.nlm.nih.gov/pubmed/31698056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104668 |
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