Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade

BACKGROUND & AIMS: Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with advanced HCC are non-responders to ICB monotherapy. Cytotoxic chemotherapy has been proposed to modulate the tumor microenvironment (TME) and sensiti...

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Detalhes bibliográficos
Publicado no:JHEP Rep
Main Authors: Kwong, Tsz Tung, Wong, Chi Hang, Zhou, Jing Ying, Cheng, Alfred Sze Lok, Sung, Joseph Jao Yiu, Chan, Anthony Wing Hung, Chan, Stephen Lam
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876565/
https://ncbi.nlm.nih.gov/pubmed/33604533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2020.100224
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