Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

BACKGROUND: Chr17q12-21.2 region is the strongest and most consistently associated region with asthma susceptibility. The functional genes or single nucleotide polymorphisms (SNPs) are not obvious due to linkage disequilibrium. OBJECTIVES: Whole-genome sequence and RNAseq from human bronchial epithe...

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Bibliographic Details
Published in:J Allergy Clin Immunol
Main Authors: Li, Xingnan, Christenson, Stephanie A., Modena, Brian, Li, Huashi, Busse, William W., Castro, Mario, Denlinger, Loren C., Erzurum, Serpil C., Fahy, John V., Gaston, Benjamin, Hastie, Annette T., Israel, Elliot, Jarjour, Nizar N., Levy, Bruce D., Moore, Wendy C., Woodruff, Prescott G., Kaminski, Naftali, Wenzel, Sally E., Bleecker, Eugene R., Meyers, Deborah A.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876167/
https://ncbi.nlm.nih.gov/pubmed/32795586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.07.030
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