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A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes

Many preclinical and clinical studies of hematopoietic stem cell-based gene therapy (GT) are based on the use of lentiviruses as the vector of choice. Assessment of the vector titer and transduction efficiency of the cell product is critical for these studies. Efficacy and safety of the modified cel...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Garcia-Perez, Laura, van Eggermond, Marja C.J.A., Maietta, Elisa, van der Hoorn, Marie-Louise P., Pike-Overzet, Karin, Staal, Frank J. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876092/
https://ncbi.nlm.nih.gov/pubmed/33584681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.607991
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